For me, I have several principal book series and sagas that I hold above all others. Starfist, being the top, Sword of Truth by Goodkind as the Second, Asimov's Foundation Series and the Robots series (all being connected) as third, and Raymond Feist's Midkemia books including the multiple sagas named in order of The Riftwar Saga, the Riftwar Legacy, the Serpent War, the Conclave of Shadows, and the new one which I havn't had the chance to get yet.
Unless I am missing my mark, the most famous book of that saga is either Magician, or Betrayal at Krondor, which was also a computer game made durring the previous decade.
It all comes down to this: It starts out like any good fantacy series, and gets progresivly more indepth, twisted, tangled, and intertwined. Each consecutive book has chacters from previous sagas reaching across at least one hundred years from book 1 to book 14 or so. It involves gods and men, deamons and aliens, magic and technology. It is worth the time and effort to read all of them, because the character, though different from every other series I have read, they jump out of their books and have the same 'realness' that any character from STARFIST has.
Not to mention, the books all have thier moments of pure genious and hilarity in them.